MOTS-C is a mitochondria-derived peptide naturally produced in the body and involved in metabolic regulation. It helps improve insulin sensitivity, increase glucose uptake, and enhance cellular energy balance. MOTS-C has been studied for its potential effects on fat loss, endurance, and healthy aging. It appears to work by activating AMPK and improving mitochondrial function. Synthetic MOTS-C is used mainly in research and experimental fitness contexts. It is typically administered by subcutaneous injection. MOTS-C is not approved for medical use, and long-term human safety data are limited.
Dosing Mots-c:
MOTS-c is a 16–amino-acid mitochondrial-derived peptide (MDP) that acts as a metabolic regulator, primarily through AMPK activation. Preclinical studies show it enhances insulin sensitivity, promotes fat oxidation, improves exercise capacity, and counters age-related metabolic decline.
Reconstitute: Add 3.0 mL bacteriostatic water → ~3.33 mg/mL concentration.
Typical daily range: 200–1,000 mcg once daily (gradual titration over 10 weeks).
Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.3 mcg on a U-100 insulin syringe.