MGF (Mechano Growth Factor) is a splice variant of IGF-1 that is produced naturally in muscle tissue in response to mechanical stress such as resistance training. Its main role is to activate muscle satellite cells, which help repair damaged muscle fibers and support muscle growth. Unlike systemic IGF-1, MGF acts mostly locally at the muscle where it is released. It has a very short half-life, meaning its effects are brief and tightly regulated. Synthetic MGF is used experimentally in research and bodybuilding contexts to enhance recovery. MGF is not approved for medical use and has limited human clinical evidence. Long-term safety and optimal dosing remain unclear
Dosing MGF:
suggested daily titration approach.
• Start: 100 mcg daily; increase by ~50 mcg weekly as tolerated.
• Target: 250–300 mcg daily by Weeks 4–8.
• Frequency: Once per day (subcutaneous).
• Cycle Length: 8–12 weeks; optional extension to 16 weeks.
• Timing: Any consistent time; rotate injection sites.